Cortical and Subcortical Structural Morphometric Profiles in Individuals with Nonaffective and Affective Early Illness Psychosis

Abstract Research has found strong evidence for common and distinct morphometric brain abnormality profiles in nonaffective psychosis (NAff-P) affective (Aff-P). Due to chronicity prolonged medication exposure confounds, it is crucial examine structural morphometry early the course of psychosis. Using Human Connectome Project-Early Psychosis data, multivariate profile analyses were implemented regional cortical thickness, surface area, subcortical volume, ventricular volume healthy control (HC; n = 56), illness NAff-P (n 83), Aff-P 30) groups after accounting normal aging. Associations with symptom severity, functioning, cognition also examined. Group significantly nonparallel differed level thickness (P < .001), having widespread thinning relative HC some regions showing greater deficits than others. Significant nonparallelism group was evident area .006), N-Aff-P differing from each other .001). For there significant an enlarged left pallidum smaller accumbens hippocampus .028), a amygdala HC. had larger basal ganglia compared Aff-P. Furthermore, ventricles .055) Additionally, associated increased manic symptoms Overall, this study abnormalities Aff-P, providing both shared disease-specific pathophysiological processes.